The gene most commonly associated with narcolepsy is called HLA-DQB1. HLA-DQB1 encodes a component of the human leukocyte antigen complex, which is an important part of the immune system. There are several hundred different HLA-DQB1 alleles. HLA-DQB1 genotyping determines the presence or absence of the DQB1*06:02 allele, which is strongly associated with an increased risk of narcolepsy.
The Narcolepsy (HLA-DQB1*06:02) Genotyping Test uses high resolution Sequence Based Typing (SBT) technology to confirm an individual’s HLA-DQB1 genotype. SBT testing technology is able to distinguish whether an individual has two copies of HLA-DQB1*06:02 (homozygous), one copy of HLA-DQB1*06:02 (heterozygous) or whether an individual is clear of the HLA-DQB1*06:02 allele.
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